منابع مشابه
Tyrosol is a quorum-sensing molecule in Candida albicans.
The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates th...
متن کاملThe metabolic basis of Candida albicans morphogenesis and quorum sensing.
Candida albicans is a polymorphic fungus that has the ability to rapidly switch between yeast and filamentous forms. The morphological transition appears to be a critical virulence factor of this fungus. Recent studies have elucidated the signal transduction pathways and quorum sensing molecules that affect the morphological transition of C. albicans. The metabolic mechanisms that recognize, an...
متن کاملCandida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration.
The polymorphic commensal fungus Candida albicans causes life-threatening disease via bloodstream and intra-abdominal infections in immunocompromised and transplant patients. Although host immune evasion is a common strategy used by successful human fungal pathogens, C. albicans provokes recognition by host immune cells less capable of destroying it. To accomplish this, C. albicans white cells ...
متن کاملQuorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.
The inoculum size effect in the dimorphic fungus Candida albicans results from production of an extracellular quorum-sensing molecule (QSM). This molecule prevents mycelial development in both a growth morphology assay and a differentiation assay using three chemically distinct triggers for germ tube formation (GTF): L-proline, N-acetylglucosamine, and serum (either pig or fetal bovine). In all...
متن کاملProduction of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development.
Tyrosol and farnesol are quorum-sensing molecules produced by Candida albicans which accelerate and block, respectively, the morphological transition from yeasts to hyphae. In this study, we have investigated the secretion of tyrosol by C. albicans and explored its likely role in biofilm development. Both planktonic (suspended) cells and biofilms of four C. albicans strains, including three mut...
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ژورنال
عنوان ژورنال: Nippon Ishinkin Gakkai Zasshi
سال: 2006
ISSN: 0916-4804,1882-0476
DOI: 10.3314/jjmm.47.263